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Abnormal Global Brain Functional Connectivity in Primary Insomnia Patients: A Resting-State Functional MRI Study
Chao-Qun Yan1,2, Xu Wang3, Jian-Wei Huo4
1Department of Acupuncture and Moxibustion, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.
Frontiers in Neurology
|November 20, 2018
Summary
Primary insomnia patients show altered brain network hubs, specifically in the left inferior frontal gyrus and middle temporal gyrus, impacting sleep quality. These findings reveal key brain functional disruptions in insomnia.
Area of Science:
- Neuroscience
- Medical Imaging
- Sleep Medicine
Background:
- Resting-state fMRI reveals disrupted brain networks in primary insomnia (PI).
- The exact causes and mechanisms of PI remain unclear.
- Insomnia symptoms are linked to complex brain network organization.
Purpose of the Study:
- To investigate abnormal intrinsic functional hubs in PI patients.
- Utilized voxel-wise degree centrality (DC) and seed-based functional connectivity (FC) analyses.
- To correlate brain function changes with clinical insomnia features.
Main Methods:
- 26 PI patients and 28 healthy controls underwent resting-state fMRI.
- Whole-brain DC analysis identified group differences.
- Seed-based FC calculated from altered DC regions, with correlation to clinical data.
Main Results:
- PI patients had lower DC in left inferior frontal gyrus (IFG) and middle temporal gyrus (MTG), higher DC in right precuneus.
- Decreased FC observed between left MTG and left posterior cingulate cortex (PCC).
- Reduced left IFG DC and decreased left PCC FC correlated with insomnia severity.
Conclusions:
- PI patients exhibit abnormal intrinsic functional hubs (left IFG, MTG, right precuneus).
- Abnormal seed-based functional connectivity was identified in these hubs.
- Findings enhance understanding of brain function's role in PI symptoms.
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