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Anti-PD-1 therapy for clinical treatment of lymphoma: a single-arm meta-analysis

Zhe Geng1, Yi Xiao1, Xiao-Jian Zhu1

  • 1Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China.

Oncotarget
|November 20, 2018
PubMed

Insights

Anti-PD-1 therapy is effective for lymphoma, especially in patients with PD-L1 overexpression. This treatment demonstrated significant benefits in overall response rates and survival outcomes, with manageable side effects.

Area of Science:

  • Oncology
  • Immunotherapy
  • Hematology

Background:

  • Anti-PD-1 antibodies have shown promise in treating various lymphoma subtypes.
  • Understanding which specific lymphoma subtypes benefit most and optimal therapeutic strategies is crucial.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the efficacy of anti-PD-1 antibodies in different lymphoma subtypes.
  • To identify the best anti-PD-1 therapeutic modalities for lymphoma treatment.

Main Methods:

  • A systematic literature search was conducted across PubMed, Web of Science, and The Cochrane Library.
  • Quantitative meta-analysis was employed to pool data on overall response rate (ORR), progression-free survival (PFS), complete remission rate (CRR), overall survival (OS), and adverse events (AEs).
  • Random-effects meta-analysis and heterogeneity statistics (Q and I² ) were used for data analysis.

Main Results:

  • The meta-analysis included 9 studies, revealing significant heterogeneity.
  • Patients with PD-L1 overexpression showed significantly better outcomes (ORR: 0.74) compared to PD-L1-negative patients (ORR: 0.2).
  • Statistically significant improvements were observed in CRR, PFS, and OS for PD-L1-positive patients. Pooled incidence of all-grade AEs was 0.84, and grade-3/4 AEs was 0.21.

Conclusions:

  • Anti-PD-1 therapy offers significant benefits for relapsed or refractory lymphoma patients with PD-L1 overexpression.
  • Approved PD-1 inhibitors demonstrated a favorable safety profile and were well-tolerated in the studied population.
Keywords:
Anti-PD1 antibodiesclinical activitylymphomameta-analysissafety

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