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Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
09:02

Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation

Published on: November 26, 2018

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Is there a role for the platelet-to-lymphocyte ratio in chronic lymphocytic leukemia?

Ziad Bakouny1, Elie El Rassy1, Fares Yared1

  • 1Department of Hematology-Oncology, Hotel-Dieu de France University Hospital, Faculty of Medicine, Saint Joseph University, Beirut, Lebanon.

Future Science OA
|November 20, 2018
PubMed

Insights

The platelet-to-lymphocyte ratio (PLR) did not prove to be a reliable prognostic biomarker for chronic lymphocytic leukemia (CLL). Further research is needed to identify effective prognostic markers for CLL patient outcomes.

Area of Science:

  • Hematology
  • Oncology
  • Clinical Research

Background:

  • The platelet-to-lymphocyte ratio (PLR) is investigated in chronic lymphocytic leukemia (CLL) due to the involvement of platelets and lymphocytes in CLL pathogenesis.
  • PLR may influence treatment decisions in CLL management.

Purpose of the Study:

  • To evaluate the prognostic role of PLR in chronic lymphocytic leukemia (CLL).
  • To assess the association of PLR with watchful waiting duration, postdiagnosis survival, and postchemotherapy survival in CLL patients.

Main Methods:

  • Retrospective analysis of demographic and clinical data from 100 CLL patients diagnosed between 1989 and 2013.
  • Cox regression models were employed to analyze the impact of PLR on clinical outcomes.

Main Results:

  • Univariable analysis showed a correlation between PLR and watchful waiting duration (HR=0.48, p=0.018).
  • Multivariable analysis revealed that Binet staging and lymphocyte count were significant predictors of watchful waiting duration.
  • Age and lymphocyte count were identified as determinants of postdiagnosis survival.

Conclusions:

  • The platelet-to-lymphocyte ratio (PLR) does not appear to be a significant prognostic biomarker for CLL.
  • Established factors like Binet staging, lymphocyte count, and age are more critical in predicting CLL patient outcomes.
Abstract

Keywords:
CLLPLRchronic lymphocytic leukemiaplatelet-to-lymphocyte ratio

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