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Spermidine/spermine N1-acetyltransferase-1 as a diagnostic biomarker in human cancer
Andrew W Maksymiuk1,2,1,2, Daniel S Sitar2,3,2,3, Rashid Ahmed4,4
1Cancer Care Manitoba, Winnipeg, Manitoba, R3E 0V9, Canada.
Aim:
SSAT-1 is an enzyme that plays a critical role in cell growth. Amantadine, a FDA-approved antiviral drug, is a substrate for SSAT-1. The utility of amantadine as an agent to demonstrate elevated SSAT-1 activity linked to cancer was conducted.
Results:
High levels of SSAT-1 expression were measured in tumor human cell lines, and in breast, prostate and lung tumor tissue. An increase in the urinary levels of acetylated amantadine in cancer patients was observed.
Conclusion:
Increases in SSAT-1 contents in tumor tissue could be of value in targeting cancers with high SSAT-1 expression for confirmation/quantification. The high levels of acetylated amantadine could be used as a simple and useful screening test for the presence of cancer.
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