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Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
Published on: July 3, 2018
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MicroRNAs in heart and circulation during physical exercise.
Lijun Wang1, Yicheng Lv1, Guoping Li2
1Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai 200444, China.
Journal of Sport and Health Science
|November 20, 2018
Summary
Exercise training impacts microRNAs (miRNAs), small molecules regulating genes, in the heart and circulation. These miRNAs show potential for treating cardiovascular diseases and assessing physical performance.
Area of Science:
- Cardiovascular Physiology
- Molecular Biology
- Biochemistry
Background:
- Exercise training confers cardiovascular benefits.
- MicroRNAs (miRNAs) are key regulators of gene expression.
- Exercise alters cardiac and circulating miRNA levels.
Purpose of the Study:
- To review miRNA regulation during exercise in cardiovascular diseases.
- To examine the role of circulating miRNAs post-exercise.
Main Methods:
- Literature review of studies on exercise intervention and miRNAs.
- Analysis of miRNA expression changes in various cardiovascular conditions.
- Review of circulating miRNA regulation by exercise.
Main Results:
- Exercise alters miRNA expression in pathological cardiac conditions like hypertrophy, fibrosis, and infarction.
- Circulating miRNAs are modulated by exercise training.
- miRNAs are implicated in ischemia-reperfusion injury and heart failure.
Conclusions:
- MicroRNAs are promising therapeutic targets for cardiovascular diseases.
- Circulating miRNAs may serve as biomarkers for physical performance.
- Exercise-induced miRNA modulation offers novel treatment strategies.
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