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Exploring intermediate cell states through the lens of single cells
Adam L MacLean1, Tian Hong2, Qing Nie1,3
1Department of Mathematics and Center for Complex Biological Systems, University of California, Irvine, CA 92697, United States.
Current Opinion in Systems Biology
|November 20, 2018
Summary
Intermediate cell states (ICSs) are crucial for understanding cell development and function. This study defines ICSs, reviews their evidence and functions, and outlines methods for their identification from single-cell data.
Area of Science:
- Cell biology
- Developmental biology
- Single-cell genomics
Background:
- The increasing complexity of cell state atlases necessitates robust characterization methods.
- Understanding cell transitions is key to deciphering biological processes.
- Intermediate cell states (ICSs) represent dynamic phases in cellular development.
Purpose of the Study:
- To define and discuss the significance of intermediate cell states (ICSs).
- To review the evidence for ICS existence and their relevance across different tissues.
- To explore potential functions of ICSs and methods for their identification.
Main Methods:
- Literature review and synthesis of existing evidence for ICSs.
- Conceptual framework for understanding ICS functions.
- Discussion of analytical approaches for identifying ICSs from single-cell data and computational models.
Main Results:
- Provides a clear definition and evidence supporting the existence of ICSs.
- Highlights the relevance of ICSs in various biological tissues.
- Lists potential functional roles of ICSs with illustrative examples.
Conclusions:
- Intermediate cell states (ICSs) play a vital role in cellular dynamics and tissue function.
- Methods for identifying and characterizing ICSs from single-cell data are essential for advancing cell biology.
- Further research into ICSs will enhance our understanding of developmental trajectories and cellular plasticity.
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