A Scalable Optoelectronic Neural Probe Architecture With Self-Diagnostic Capability

Area of Science:

• Neuroscience
• Biomedical Engineering
• Optoelectronics

Background:

• Growing demand for advanced implantable optoelectronics in neuroscience and optogenetics.
• Need for devices supporting multi-site optical stimulation, programmable radiance, safety, and miniaturization.
• Preference for simple serial interfaces over numerous control lines.

Purpose of the Study:

• To demonstrate a novel optrode structure for advanced optogenetic applications.
• To integrate multi-site optical stimulation and diagnostic sensing capabilities.
• To enable independent control and serial communication for external units.

Main Methods:

• Utilized a standard complementary metal-oxide-semiconductor (CMOS) process.
• Integrated 18 optical stimulation drivers within the optrode structure.
• Incorporated diagnostic sensing circuitry for long-term functionality assessment.
• Developed a digital control system for independent multi-site control and serial communication.

Main Results:

• Successfully demonstrated an optrode structure with 18 optical stimulation drivers.
• Integrated diagnostic sensing circuitry to monitor photonic element functionality.
• Implemented a digital control system enabling independent multi-site control and serial communication.

Conclusions:

• The developed optrode structure meets key specifications for implantable optoelectronics.
• The integrated diagnostic sensing and digital control enhance device safety and usability.
• This technology supports advancements in basic neuroscience research and optogenetic therapies for neurological disorders.