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Updated: Feb 2, 2026

Genotyping of Staphylococcus aureus by Ribosomal Spacer PCR RS-PCR
Published on: November 4, 2016
Effect of matrine on reducing damage to bovine mammary epithelial cells induced by Staphylococcus aureus
1Key lab of Ministry of Education for Protection and Utilization of Special Biological Resources in Western China, Department of College of Life Science, Ningxia University, Helanshan Road No. 539, Yinchuan, Ningxia, 750021, P. R. China.
Abstract:
Taking bacterial virulence factors as targets is a new therapy for treating host bacterial infection. The aim of this study was to investigate the effect of matrine on α-hemolysin production of Staphylococcus aureus (S. aureus) and reducing the damage to bovine mammary epithelial cells (BMECs) induced by S. aureus α-hemolysin. Subinhibitory concentrations of matrine decreased the production of α-hemolysin in none dose-dependent manner and matrine exhibited a protective effect on S. aureus-induced BMECs injury. The results indicated that the structure of matrine may potentially be used as a basic structure for development of drugs aimed at curing and preventing dairy bovine mastitis.
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