Related Experiment Video
Updated: Feb 2, 2026
09:03
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
10.1K
[Diabetology and solid organ transplantation]
László Wagner1, István Wittmann2, László Piros1
1Transzplantációs és Sebészeti Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Baross u. 23., 1082.
Orvosi Hetilap
|November 20, 2018
Summary
Diabetes significantly impacts kidney health, increasing risks for diabetic nephropathy and other kidney diseases. Early intervention and transplantation, especially with living donors, improve outcomes, though post-transplant diabetes requires careful management.
Area of Science:
- Nephrology
- Endocrinology
- Transplantation Medicine
Background:
- Diabetes mellitus is a major risk factor for various kidney diseases, most notably diabetic nephropathy.
- Diabetic nephropathy remains a leading cause of kidney failure, necessitating dialysis or transplantation.
- Cardiovascular complications, cerebrovascular insults, and peripheral arterial disease are significant mortality predictors in diabetic patients.
Purpose of the Study:
- To review the multifaceted impact of diabetes on kidney health and associated complications.
- To discuss current management strategies for diabetic kidney disease and transplantation outcomes.
- To highlight the challenges and management of carbohydrate metabolism disorders in kidney transplant recipients.
Main Methods:
- Literature review and synthesis of current knowledge on diabetes and kidney disease.
- Analysis of outcomes related to kidney transplantation in diabetic patients.
- Discussion of post-transplant diabetes mellitus (PTDM) and its management.
Main Results:
- Diabetic nephropathy, though improving, is a primary driver for dialysis and transplantation.
- Simultaneous pancreas-kidney transplantation can achieve normoglycemia and halt complication progression in type 1 diabetes.
- Post-transplant hyperglycemia is common, with approximately one-third developing persistent PTDM, often due to insulin secretion defects and resistance.
Conclusions:
- Comprehensive management of diabetes and its complications is crucial, with preemptive transplantation and living donation offering better outcomes.
- Pancreas transplantation alongside kidney transplantation is a viable option for type 1 diabetes.
- Careful monitoring and management of carbohydrate metabolism are essential in all kidney transplant donors and recipients, particularly for PTDM.
Keywords:
diabetes mellitushasnyálmirigy-átültetéskidney transplantationpancreas transplantationposttransplantation diabetes mellitusposzttranszplantációs diabetes mellitusveseátültetésMore Related Videos
08:07Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
Published on: September 6, 2017
10.6K
06:53Author Spotlight: Magnetometric Characterization of Intermediates in the Solid-State Electrochemistry of Redox-Active Metal-Organic Frameworks
Published on: June 9, 2023
2.7K
Related Concept Videos
02:37Metallic Solids
20.6K
Metallic solids such as crystals of copper, aluminum, and iron are formed by metal atoms. The structure of metallic crystals is often described as a uniform distribution of atomic nuclei within a “sea” of delocalized electrons. The atoms within such a metallic solid are held together by a unique force known as metallic bonding that gives rise to many useful and varied bulk properties.
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
20.6K
02:22Structures of Solids
17.7K
Solids in which the atoms, ions, or molecules are arranged in a definite repeating pattern are known as crystalline solids. Metals and ionic compounds typically form ordered, crystalline solids. A crystalline solid has a precise melting temperature because each atom or molecule of the same type is held in place with the same forces or energy. Amorphous solids or non-crystalline solids (or, sometimes, glasses) which lack an ordered internal structure and are randomly arranged. Substances that...
17.7K
02:18Network Covalent Solids
16.2K
Network covalent solids contain a three-dimensional network of covalently bonded atoms as found in the crystal structures of nonmetals like diamond, graphite, silicon, and some covalent compounds, such as silicon dioxide (sand) and silicon carbide (carborundum, the abrasive on sandpaper). Many minerals have networks of covalent bonds.
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...
16.2K
02:54Molecular and Ionic Solids
20.1K
Crystalline solids are divided into four types: molecular, ionic, metallic, and covalent network based on the type of constituent units and their interparticle interactions.
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
Molecular Solids
Molecular crystalline solids, such as ice, sucrose (table sugar), and iodine, are solids that are composed of neutral molecules as their constituent units. These molecules are held together by weak intermolecular forces such as London dispersion forces, dipole-dipole interactions, or hydrogen bonds, which...
20.1K
02:26Molecular Comparison of Gases, Liquids, and Solids
55.1K
Particles in a solid are tightly packed together (fixed shape) and often arranged in a regular pattern; in a liquid, they are close together with no regular arrangement (no fixed shape); in a gas, they are far apart with no regular arrangement (no fixed shape). Particles in a solid vibrate about fixed positions (cannot flow) and do not generally move in relation to one another; in a liquid, they move past each other (can flow) but remain in essentially constant contact; in a gas, they move...
55.1K
01:09Levels of Organization
140.8K
Biological organization is the classification of biological structures, ranging from atoms at the bottom of the hierarchy to the Earth's biosphere. Each level of the hierarchy represents an increase in complexity that builds upon the previous level.
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
Molecules Are Composed of Atoms, and Biomolecules Are Assembled from Molecules:
The most basic levels include atoms, molecules, and biomolecules. Atoms, the smallest unit of ordinary matter, are composed of a nucleus and electrons. Molecules...
140.8K