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Updated: Feb 2, 2026
Murine Corneal Transplantation: A Model to Study the Most Common Form of Solid Organ Transplantation
Published on: November 17, 2014
[Solid organ transplantation in childhood]
Antal Dezsőfi1, György Reusz1, Lajos Kovács1
1I. Gyermekgyógyászati Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Bókay J. u. 53., 1083.
Insights
Pediatric organ transplantation is a successful therapy for children with end-stage organ failure. Challenges unique to pediatric patients require specialized approaches for successful outcomes.
Area of Science:
- Pediatric medicine
- Transplantation surgery
- Immunology
Background:
- Pediatric organ transplantation is an established therapy for end-stage organ failure in children.
- Childhood diseases leading to organ failure differ from adult conditions.
- Unique pediatric challenges include size discrepancies, specialized infections, and altered drug responses.
Purpose of the Study:
- To review the current status and challenges of pediatric organ transplantation.
- To highlight the successes and complexities in pediatric transplant care.
Main Methods:
- Review of current literature and clinical practices in pediatric organ transplantation.
- Analysis of specific pediatric challenges in pre- and post-transplant management.
Main Results:
- Pediatric organ transplantation is a widely accepted and available treatment.
- Significant challenges exist, including donor-recipient size matching, pediatric-specific infections, and modified drug pharmacokinetics.
- Despite challenges, pediatric transplantation has become a success in Hungarian healthcare.
Conclusions:
- Pediatric organ transplantation is a viable and successful treatment option for children.
- Addressing unique pediatric challenges is crucial for optimizing transplant outcomes.
- Continued advancements and specialized care contribute to the success of pediatric organ transplantation.
Abstract:
Paediatric organ transplantation today is considered and accepted and widely available therapy in children with end-stage organ failure. It is important to know that in childhood, diseases leading to end-stage organ failure differ from those in adults. Beside this, in children there are different surgical and paediatric challenges before and after transplantation (size differences of the patient and donor organ, special and paediatric infections, different pharmacokinetics and pharmacodynamics of immunosuppressive drugs, noncompliance). However, paediatric organ transplantation in the last decades became a success story of the Hungarian health care owing to several working groups in Hungary and outside the country. Orv Hetil. 2018; 159(46): 1948-1956.
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