Related Experiment Video
Updated: Feb 2, 2026

Author Spotlight: Developing Acetyl-Click Assay for HAT1 Inhibitor Screening
Published on: January 26, 2024
Minor acetylated metabolites from Euphrasia rostkoviana
Michele D'Ambrosio1, Alexandru Ciocarlan2, Aculina Aricu2
1Laboratory of Bioorganic Chemistry, Department of Physics, Università degli Studi di Trento, Trento, Italy.
Abstract:
The phenylethanoids rostkovianoside, 6'-O-acetylcrassifolioside and the flavonoid rutin 3‴-acetate, were isolated from the methanolic extract of the aerial parts of Euphrasia rostkoviana Hayne. The structures of these previously undescribed compounds were elucidated by interpretation of spectroscopic data. The acetylation of rutin was also carried out and four ester derivatives were spectroscopically characterized. Finally, a chromatographic method was established to easily identify the acetylated position.
Related Concept Videos
Minor Losses in Pipes
Valves play a significant role in generating minor losses by obstructing or redirecting the fluid flow. When a valve is closed or partially closed, it restricts the flow...
Phase II Reactions: Acetylation Reactions
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...
Effect of Hepatic Disease on Pharmacokinetics: Active Drug, Metabolite and Fraction of Metabolized Drug
Pyruvate Oxidation
First, the enzyme pyruvate dehydrogenase removes the carboxyl group from pyruvate and releases it as carbon dioxide. The stripped molecule is then oxidized and releases electrons, which are then picked up by NAD+...
Covalently Linked Protein Regulators
These groups modify specific amino acids in a protein....
Riboswitches
The aptamer has high specificity for a particular metabolite which allows riboswitches to specifically regulate...

