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Updated: Feb 2, 2026

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An unusual case of a grade I meningioma with perineural spread

Mohammed Fadelalla1, Avinash Kumar Kanodia2, John Brunton2

  • 1Department of Neurosurgery, NHS Tayside, Dundee, United Kingdom.

British Journal of Neurosurgery
|November 20, 2018
PubMed

Insights

A rare case of a benign brain tumor, Meningothelial Meningioma, exhibited unusual perineural spread. This finding suggests that perineural spread is not limited to aggressive tumors.

Area of Science:

  • Neurology
  • Neurosurgery
  • Pathology

Background:

  • Meningiomas are typically benign tumors arising from the meninges.
  • Perineural spread is a known phenomenon in some malignant brain tumors, but is rarely reported in benign meningiomas.

Observation:

  • A 39-year-old female presented with intermittent diplopia and headaches.
  • Imaging revealed a WHO Grade I Meningothelial Meningioma with extensive perineural spread, a highly unusual presentation.

Findings:

  • This case represents the first documented instance of perineural spread in a Meningothelial Meningioma.
  • The observed perineural spread highlights that this behavior is not exclusive to aggressive central nervous system neoplasms.

Implications:

  • The findings broaden the understanding of meningioma behavior and potential spread patterns.
  • This case underscores the importance of considering perineural spread even in histologically benign tumors.
  • Further research into the mechanisms of perineural spread in meningiomas is warranted.
Keywords:
Meningiomameningothelial meningiomaperineural spread

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