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Current Trends in Protein Engineering: Updates and Progress.

Rajeshwari Sinha1, Pratyoosh Shukla2

  • 1Independent Researcher, New Delhi, India.

Current Protein & Peptide Science
|November 20, 2018
PubMed
Summary

Protein engineering enhances biomolecule properties for diverse applications in health and industry. This review covers current trends and future directions in protein design and development.

Keywords:
Protein engineeringcomputational methodsde novo designdirected evolutionrational designsemi-rational approach.

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Area of Science:

  • Biotechnology
  • Biochemistry
  • Molecular Biology

Background:

  • Proteins are vital biomolecules with broad applications in medicine, industry, and research.
  • Protein engineering is a key biotechnological approach to improve protein functionality and applicability.
  • Engineered proteins offer economically viable solutions for industrial and healthcare sectors.

Purpose of the Study:

  • To review current protein engineering methodologies.
  • To highlight recent advancements in the field.
  • To explore futuristic aspects of novel protein design.

Main Methods:

  • Rational design
  • Directed evolution
  • De novo design
  • Computational approaches

Main Results:

  • Strategic protein engineering improves enzymatic properties, stability, and catalytic activity.
  • Enhanced protein applicability supports synthetic biology and metabolic engineering.
  • Commercialization of engineered proteins yields significant economic benefits.

Conclusions:

  • Protein engineering is a dynamic field with continuous innovation.
  • Advanced techniques are being explored for developing novel proteins with superior properties.
  • The field holds promise for future breakthroughs in biotechnology and medicine.