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Updated: Feb 2, 2026

A Multi-Modal Approach to Assessing Recovery in Youth Athletes Following Concussion
Published on: September 25, 2014
Resting-state functional connectivity after concussion is associated with clinical recovery
Mayank Kaushal1, Lezlie Y España1, Andrew S Nencka2
1Department of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin.
Sport-related concussion (SRC) alters whole-brain functional connectivity, with changes appearing later and linked to persistent symptoms. Recovery in athletes involves delayed connectivity shifts, not immediate ones.
Area of Science:
- Neuroscience
- Sports Medicine
- Radiology
Background:
- Longitudinal imaging is crucial for understanding sport-related concussion (SRC) recovery.
- Resting-state functional connectivity (rs-FC) changes may reflect underlying neurological recovery.
- The relationship between rs-FC alterations and clinical outcomes post-SRC requires further investigation.
Purpose of the Study:
- To examine longitudinal changes in whole-brain rs-FC following SRC.
- To explore associations between rs-FC and clinical recovery measures in athletes.
- To characterize the time course of physiological recovery post-SRC.
Main Methods:
- Prospective study of high school and collegiate football athletes.
- Multi-band resting-state fMRI used to assess rs-FC at multiple time points (acute, sub-acute).
- Network-based statistics and average nodal strength analyzed for whole-brain connectivity.
Main Results:
- Concussed athletes showed elevated symptoms and deficits acutely and at 8 days post-injury.
- Global increase in rs-FC observed at 8 days post-concussion, not at other time points.
- Delayed rs-FC alterations were associated with the presence of self-reported symptoms at 8 days.
Conclusions:
- Whole-brain rs-FC alterations following SRC are delayed in onset.
- These connectivity changes are linked to the persistence of self-reported symptoms.
- Findings highlight the importance of longitudinal assessment in SRC recovery.
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05:48Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
Published on: September 21, 2018
07:13Cerebral Blood Flow-Based Resting State Functional Connectivity of the Human Brain using Optical Diffuse Correlation Spectroscopy
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