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Updated: Feb 2, 2026

Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
Unveiling Ga(III) phthalocyanine-a different photosensitizer in neuroblastoma cellular model
Carolina Constantin1,2, Andreea-Roxana Lupu1, Tudor Emanuel Fertig3
1Immunology Department, "Victor Babes" National Institute of Pathology, Bucharest, Romania.
Abstract:
Phthalocyanines (Pc) and their metallated derivatives are strongly considered for photodynamic therapy (PDT) possessing unique properties as possible new photosensitizers (PS). We have used toxicological assessments, real-time monitoring of cellular impedance, and imagistic measurements for assessing the in vitro dark toxicity and PDT efficacy of Ga(III)-Pc in SHSy5Y neuroblastoma cells. We have established the non-toxic concentration range of Ga(III)-Pc, a compound which shows a high intracellular accumulation, with perinuclear distribution in confocal microscopy. By choosing Ga(III)Pc non-toxic dose, we performed in vitro experimental PDT hampering cellular proliferation. Our proposed Ga(III)-Pc could complete a future PS panel for neuroblastoma alternate therapy.
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