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Updated: Feb 2, 2026

An Adoptive Transfer Model of Rheumatoid Arthritis in Mice

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Published on: June 6, 2025

Articular abnormalities that may mimic arthritis.

Adam Greenspan¹, Andrew J Grainger²

¹Department of Radiology, University of California School of Medicine, Sacramento, California, USA.

Journal of Ultrasonography

|November 20, 2018

Summary

Several joint conditions mimic arthritis symptoms. This article discusses synovial osteochondromatosis, pigmented villonodular synovitis, synovial hemangioma, and lipoma arborescens as differential diagnoses for joint pain.

Keywords:

arthritis lipoma arborescens pigmented villonodular synovitis synovial hemangioma synovial osteochondromatosis

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Area of Science:

Orthopedics
Rheumatology
Pathology

Background:

Arthritis diagnosis can be challenging due to overlapping symptoms with other joint abnormalities.
Accurate differentiation is crucial for appropriate patient management and treatment.

Purpose of the Study:

To review and describe uncommon joint conditions that can be misdiagnosed as arthritis.
To highlight key features differentiating these entities from common arthritic conditions.

Main Methods:

Literature review of synovial osteochondromatosis, pigmented villonodular synovitis, synovial hemangioma, and lipoma arborescens.
Discussion of the characteristic pathological and clinical presentations of each condition.

Main Results:

Synovial osteochondromatosis: benign cartilaginous nodules in synovium.
Pigmented villonodular synovitis: locally destructive fibrohistiocytic proliferation.
Synovial hemangioma: rare benign vascular lesion, often in the knee.
Lipoma arborescens: non-neoplastic lipomatous proliferation with tree-like morphology.

Conclusions:

These distinct synovial disorders require careful consideration in the differential diagnosis of joint complaints.
Recognizing the unique features of each condition aids in accurate diagnosis and targeted therapy, avoiding misclassification as arthritis.