Related Experiment Video
Updated: Feb 2, 2026

Profiling of Estrogen-regulated MicroRNAs in Breast Cancer Cells
Published on: February 21, 2014
Preventive effects of oxytocin and oxytocin receptor in breast cancer pathogenesis
Mehdi Ariana1, Majid Pornour2, Saeedeh Sarafraz Mehr1
1Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Aim:
Modifications of oxytocin (OT) concentration and OT receptor (OXTR) expression level have different effects on breast cancer-derived cells. This study was conducted to evaluate OT variation in breast cancer patients and to evaluate OXTR expression changes in breast cancer tissues.
Methods:
The plasma concentrations of OT in both breast cancer patients and healthy individuals' samples were assessed. OXTR variations were then assessed in both cancerous and noncancerous breast tissues.
Results:
OT had an increase in breast cancer patients and expression of OXTR in contralateral breast was more than cancerous tissues.
Conclusion:
Despite the high levels of OT concentration in breast cancer patients, it seems that a lower expression of OXTR in cancerous tissues can be effective in the breast cancer progression.
Related Concept Videos
Cancer Prevention
Some...
Internal Receptors
Pulmonary Hypertension: Classification and Pathogenesis
There are various classifications for PH, each relating to different underlying causes and also...
Asthma: Pathogenesis and Management
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Cell-surface Signaling

