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Topical tretinoin in the treatment of aging skin
J S Weiss1, C N Ellis, J T Headington
1Department of Dermatology, University of Michigan Medical Center, Ann Arbor 48109-0314.
Journal of the American Academy of Dermatology
|July 1, 1988
Abstract:
We review the use of topical tretinoin (all-trans-retinoic acid) in the treatment of aging skin. We have found topical tretinoin capable of improving aged-appearing skin in both a double-blind, vehicle-controlled trial and our clinic patients. The most impressive improvement occurs after application of tretinoin 0.1% cream for 8 to 12 months. Side effects have been limited to a mild, transient, and clinically insignificant burning sensation in the eyes and mild irritation of tretinoin-exposed skin.