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Related Experiment Video

Updated: Feb 2, 2026

Fecal micro RNA Isolation
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A Quality-of-Life Comparison of Two Fecal Incontinence Phenotypes: Isolated Fecal Incontinence Versus Concurrent

Christy E Cauley1, Lieba R Savitt1, Milena Weinstein2

  • 1Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts.

Diseases of the Colon and Rectum
|November 20, 2018
PubMed
Summary
This summary is machine-generated.

Fecal incontinence with constipation affects nearly 70% of patients and presents a distinct phenotype with poorer quality of life. Understanding this subgroup is crucial for effective treatment strategies.

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Area of Science:

  • Gastroenterology
  • Urogynecology
  • Pelvic Floor Disorders

Background:

  • Fecal incontinence (FI) frequently co-occurs with constipation.
  • This patient subset remains poorly understood and characterized.
  • Investigating the interplay between FI and constipation is essential for comprehensive patient care.

Purpose of the Study:

  • To determine the frequency of fecal incontinence (FI) with concurrent constipation.
  • To compare quality-of-life (QoL) outcomes in patients with FI, with and without constipation.
  • To identify distinct clinical and physiological characteristics of patients with coexisting FI and constipation.

Main Methods:

  • Prospective cohort study design.
  • Utilized validated surveys: Fecal Incontinence Severity Index, Constipation Severity Instrument, Fecal Incontinence Quality of Life (FIQL) survey, Pelvic Organ Prolapse Inventory (POPI), and Urinary Distress Inventory (UDI).
  • Included anorectal manometry and defecography for physiological assessment.

Main Results:

  • 69.3% of 946 FI patients had concurrent constipation.
  • Patients with FI and constipation showed higher rates of pelvic organ prolapse (POPI) and urinary incontinence (UDI).
  • Despite less severe incontinence scores, they reported significantly lower overall health satisfaction and declining QoL with increasing constipation severity.

Conclusions:

  • Fecal incontinence with concurrent constipation represents a unique disease phenotype.
  • These patients exhibit distinct clinical and physiological findings, along with a worse overall quality of life.
  • Treatment necessitates careful consideration of pelvic organ prolapse and coordinated management of coexisting conditions.