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Related Concept Videos

Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
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Concentration Cells02:41

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A concentration cell is a type of a  voltaic cell constructed by connecting two almost identical half-cells, both based on the same half-reaction and using the same electrode, differing only in the concentration of one redox species. A concentration cell's potential, therefore, is determined only by the concentration difference of the particular redox species.
Consider the following voltaic cell:
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Solution Concentration and Dilution02:59

Solution Concentration and Dilution

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The relative amount of a given solution component is known as its concentration. Often, though not always, a solution contains one component with a concentration that is significantly greater than that of all other components. This component is called the solvent and may be viewed as the medium in which the other components are dispersed or dissolved. Solutions in which water is the solvent are, of course, very common on our planet. A solution in which water is the solvent is called an aqueous...
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Stress Concentrations01:13

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The concept of stress concentration is crucial for understanding how materials respond under bending stresses, particularly when there are irregularities or discontinuities in the material's geometry. Normally, stress in a symmetric member subjected to pure bending is assumed to be uniformly distributed across the entire cross-section. However, this assumption does not hold when there are variations in the cross-sectional geometry or the presence of notches and holes.
The stress...
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Stress Concentrations01:24

Stress Concentrations

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Stress concentration is when stress intensifies near discontinuities such as holes or abrupt cross-sectional changes in a structural member. This localized stress can often surpass the average stress within the member. The stress distribution in flat bars, either with a circular hole or varying widths connected by fillets, can be determined experimentally using a photoelastic method. The results are based on ratios of geometric parameters like the ratio of the hole's radius to the smaller...
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Concentration and Rate Law03:03

Concentration and Rate Law

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The rate of a reaction is affected by the concentrations of reactants. Rate laws (differential rate laws) or rate equations are mathematical expressions describing the relationship between the rate of a chemical reaction and the concentration of its reactants.
For example, in a generic reaction aA + bB ⟶ products, where a and b are stoichiometric coefficients, the rate law can be written as:
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Femoral Bone Marrow Aspiration in Live Mice
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Bone Marrow Aspirate Concentrate for Orthopaedic Use.

Jorge Chahla1, Jeremy A Alland, Nikhil N Verma

  • 1Jorge Chahla, MD, PhD, Midwest Orthopaedics at Rush, Chicago, IL. Jeremy A. Alland, MD, Midwest Orthopaedics at Rush, Chicago, IL. Nikhil N. Verma, MD, Midwest Orthopaedics at Rush, Chicago, IL.

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Bone marrow aspirate concentrate offers minimally invasive treatment for musculoskeletal conditions, showing promise for healing and recovery. Further research is needed to fully understand its long-term outcomes and optimize its use.

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Area of Science:

  • Orthopedics and Regenerative Medicine
  • Biologics in Musculoskeletal Repair

Background:

  • Biological therapies are gaining traction for musculoskeletal issues due to minimal invasiveness and potential for rapid healing.
  • Platelet-rich plasma, bone marrow aspirate concentrate, and cell-based therapies dominate current research in this field.
  • While promising, long-term outcomes require further investigation.

Purpose of the Study:

  • To review key aspects of bone marrow aspirate concentrate (BMAC).
  • To critically assess current evidence-based recommendations for BMAC.
  • To identify future research and development directions for BMAC.

Main Methods:

  • Literature review of bone marrow aspirate concentrate therapies.
  • Critical assessment of existing clinical evidence and guidelines.
  • Identification of research gaps and future development opportunities.

Main Results:

  • Bone marrow aspirate concentrate is an FDA-approved stem cell delivery method.
  • Compelling evidence supports its use for specific musculoskeletal indications.
  • Further research is essential for long-term outcome elucidation.

Conclusions:

  • Bone marrow aspirate concentrate presents a significant option in biological therapies for musculoskeletal conditions.
  • Evidence supports its efficacy for certain injuries, warranting clinical application.
  • Continued research is crucial for optimizing its therapeutic potential and establishing best practices.