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SYNDROME DES ANTIPHOSPHOLIPIES. À PROPOS DE 30 CAS.
Le Journal Medical Libanais. the Lebanese Medical Journal
|November 20, 2018
Summary
Antiphospholipid syndrome (APS) in Lebanon primarily affects women and often presents as primary APS. Early diagnosis is crucial to prevent severe complications like thrombosis and fetal loss, with most patients responding well to treatment.
Area of Science:
- Rheumatology
- Immunology
- Hematology
Background:
- Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by recurrent thrombosis and pregnancy complications.
- Understanding the clinical and immunological spectrum of APS in diverse populations is essential for effective management.
Purpose of the Study:
- To analyze the clinical and immunological manifestations of antiphospholipid syndrome (APS) in Lebanese patients.
- To identify specific features and outcomes of APS in this population.
Main Methods:
- Retrospective analysis of 30 hospitalized Lebanese patients diagnosed with APS between 2001 and 2013.
- Inclusion based on the Sydney criteria for APS diagnosis.
Main Results:
- Female predominance (sex ratio: 2.75) with a mean age of 43 years at diagnosis.
- Primary APS observed in 70% of cases; common manifestations include deep venous thrombosis (53%), pulmonary embolism (33%), and stroke (13%).
- High rates of fetal complications (62.5% early fetal loss) and frequent detection of anticardiolipin antibodies (83%).
Conclusions:
- Antiphospholipid syndrome in Lebanon does not appear to have unique features compared to international data.
- Primary APS is the most common form.
- Early diagnosis and intervention are vital to mitigate severe thrombotic and obstetric complications.
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