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Interleukin-33, a Potential Cytokine Expressed in Tumor Microenvironment Involves in Antitumor Immunotherapy Through

Xiaochen Li1,2, Quansheng Lv1,3,4,5, Yuehua Feng6

  • 11 Department of Immunology, School of Biology and Basic Medical Sciences, Soochow University , Suzhou, China .

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|November 20, 2018
PubMed

Interleukin-33 (IL-33) is a cytokine with pleiotropic functions in various diseases; however, its role in the antitumor immune response is still unclear. We found the expression of IL-33/ST2 in nonsmall cell lung tumor microenvironment. Furthermore, we found that IL-33 promoted effector functions of CD8+ T cells that play a critical role in antitumor immune response. In addition, we found that IL-33 enhanced tumor vaccine effector functions in mice. Altogether, these findings suggest that IL-33, through facilitates CD8+ T cells in microenvironment to provide a profound effect in antitumor immunotherapy.

Keywords:
CD8+ T cellIFN-γIL-33NSCLCST2immunotherapy

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