Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal calcification in preterm infants: pathophysiology and long-term sequelae.

F Ezzedeen1, R D Adelman, C E Ahlfors

  • 1Department of Pediatrics, School of Medicine, University of California, Sacramento 95817.

The Journal of Pediatrics
|September 1, 1988
PubMed
Summary

Nephrocalcinosis in preterm infants receiving loop diuretics often resolves but can persist. Renal function may be compromised despite calcification improvement, highlighting the need for ongoing monitoring.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Risk Factors for Hospitalization of Home Hospice Enrollees Development and Validation of a Predictive Tool.

The American journal of hospice & palliative care·2016
Same author

Integration of geriatric mental health screening into a primary care practice: a patient satisfaction survey.

International journal of geriatric psychiatry·2014
Same author

Influence of clinical status on the association between plasma total and unbound bilirubin and death or adverse neurodevelopmental outcomes in extremely low birth weight infants.

Acta paediatrica (Oslo, Norway : 1992)·2010
Same author

Unbound bilirubin predicts abnormal automated auditory brainstem response in a diverse newborn population.

Journal of perinatology : official journal of the California Perinatal Association·2009
Same author

Usefulness of the bilirubin/albumin ratio for predicting bilirubin-induced neurotoxicity in premature infants.

Archives of disease in childhood. Fetal and neonatal edition·2008
Same author

Effect of implanted insulin pumps on fluorescein transcapillary escape time in type 1 diabetes mellitus.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·2004

Area of Science:

  • Neonatology
  • Pediatric Nephrology
  • Pharmacology

Background:

  • Preterm infants with chronic lung disease often require loop diuretics.
  • Loop diuretic use is associated with an increased risk of nephrocalcinosis.
  • Nephrocalcinosis is a significant concern in the long-term health of preterm infants.

Purpose of the Study:

  • To examine the clinical course and outcomes of nephrocalcinosis in preterm infants treated with loop diuretics.
  • To assess the resolution of renal calcification and its impact on renal function over time.
  • To identify risk factors associated with nephrocalcinosis in this vulnerable population.

Main Methods:

  • Retrospective analysis of 17 preterm infants with chronic lung disease and nephrocalcinosis.
  • Evaluation of clinical data, including diuretic use and risk factors.

Related Experiment Videos

  • Serial assessments of renal calcification, renal length, and renal function (serum creatinine, GFR) via imaging and laboratory tests.

    • Main Results:

    • Nephrocalcinosis was diagnosed at a mean age of 12 weeks and associated with furosemide therapy and multiple risk factors.
    • In nine infants followed for up to 4.5 years, calcification improved in five, with four showing complete resolution.
    • Renal length was normal in most kidneys, but abnormal renal function (creatinine, GFR) was noted in four of nine patients.

    Conclusions:

    • Renal calcification in preterm infants is linked to risk factors including furosemide, and tends to decrease in the first year.
    • While calcification may resolve, some infants may experience persistent renal function impairment.
    • Long-term monitoring of renal function is crucial for preterm infants who develop nephrocalcinosis.