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Updated: Feb 2, 2026
09:21
Real Time Monitoring of Intracellular Bile Acid Dynamics Using a Genetically Encoded FRET-based Bile Acid Sensor
Published on: January 4, 2016
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Bile acids and the metabolic syndrome
Emma Rose McGlone1, Stephen R Bloom1
1Division of Diabetes, Endocrinology and Metabolism, Imperial College London, London, UK.
Annals of Clinical Biochemistry
|November 21, 2018
Summary
Bile acids regulate metabolism. Dysregulation of bile acid homeostasis is linked to obesity and metabolic diseases like type 2 diabetes, suggesting therapeutic potential.
Area of Science:
- Biochemistry
- Metabolic Regulation
- Endocrinology
Background:
- Bile acids are critical regulators of lipid, glucose, and energy metabolism.
- Obesity-related metabolic diseases, such as type 2 diabetes mellitus and non-alcoholic fatty liver disease, are characterized by disrupted bile acid homeostasis.
Purpose of the Study:
- To review the fundamental chemistry and regulation of bile acids.
- To examine the metabolic effects of bile acids.
- To discuss alterations in circulating bile acids in obesity and related conditions.
- To outline pharmaceutical strategies targeting bile acid homeostasis for metabolic disease therapy.
Main Methods:
- Literature review of bile acid chemistry and regulation.
- Analysis of metabolic effects of bile acids.
- Review of studies on circulating bile acid changes in metabolic diseases.
- Survey of therapeutic approaches involving bile acid modulation.
Main Results:
- Bile acids play a key role in metabolic control.
- Obesity and associated diseases disrupt normal bile acid function.
- Circulating bile acid profiles are altered in metabolic dysfunction.
- Targeting bile acid pathways offers therapeutic promise.
Conclusions:
- Bile acid metabolism is intrinsically linked to overall metabolic health.
- Understanding bile acid dysregulation is crucial for treating metabolic diseases.
- Pharmaceutical interventions modulating bile acid homeostasis represent a viable therapeutic avenue.
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