Related Experiment Video

Updated: Feb 2, 2026

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
12:40

Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System

Published on: December 7, 2012

29.5K

Effectiveness of high-dose glucocorticoids on hemolysis, elevating liver enzymes, and reducing platelets syndrome

Suya Kang1, Liping Zhou1, Xiaoyan Wang1

  • 1Department of Obstetrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, China.

The Journal of International Medical Research
|November 21, 2018
PubMed

Insights

High-dose glucocorticoids did not significantly improve outcomes for patients with hemolysis, elevating liver enzymes, and reducing platelets (HELLP) syndrome. The treatment showed no substantial benefits in maternal or fetal prognoses or laboratory markers.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Critical Care Medicine

Background:

  • Hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome is a severe obstetric complication.
  • Effective therapeutic strategies for HELLP syndrome remain an area of active research.
  • Glucocorticoids are sometimes used, but their efficacy requires further investigation.

Purpose of the Study:

  • To evaluate the effectiveness of high-dose glucocorticoid therapy in patients diagnosed with HELLP syndrome.
  • To assess the impact of glucocorticoids on maternal and fetal outcomes.
  • To analyze changes in key laboratory indices associated with HELLP syndrome.

Main Methods:

  • A cohort of 151 patients with HELLP syndrome was analyzed.
  • Patients were divided into treatment (high-dose glucocorticoids) and control groups.
  • Subgroup analysis was performed based on disease severity using the American Mississippi Diagnostic Criteria.

Main Results:

  • No significant differences were observed in maternal complications, including hemorrhage, ICU admission, or mortality, between groups.
  • Fetal outcomes, such as perinatal mortality and adverse event rates, did not differ significantly.
  • While one subgroup showed a higher preterm delivery rate in the treatment group, overall laboratory markers and key clinical outcomes showed no improvement.

Conclusions:

  • High-dose glucocorticoids do not appear to significantly improve maternal and fetal prognoses in HELLP syndrome.
  • The study suggests limited clinical benefit of this treatment regimen for HELLP syndrome based on current evidence.
  • Further research may be needed to explore alternative or adjunctive therapies for HELLP syndrome.
Abstract

Keywords:
GlucocorticoidHELLP syndromeblood productdexamethasonefetusmethylprednisolonepreterm deliveryprimipara

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.1K
Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation08:39

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

8.4K

Related Concept Videos

Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
777
Freezing Point Depression and Boiling Point Elevation03:12

Freezing Point Depression and Boiling Point Elevation

Boiling Point Elevation
The boiling point of a liquid is the temperature at which its vapor pressure is equal to ambient atmospheric pressure. Since the vapor pressure of a solution is lowered due to the presence of nonvolatile solutes, it stands to reason that the solution’s boiling point will subsequently be increased. Vapor pressure increases with temperature, and so a solution will require a higher temperature than will pure solvent to achieve any given vapor pressure, including one...
40.1K
Enzymes02:34

Enzymes

Inside living organisms, enzymes act as catalysts for many biochemical reactions involved in cellular metabolism. The role of enzymes is to reduce the activation energies of biochemical reactions by forming complexes with its substrates. The lowering of activation energies favor an increase in the rates of biochemical reactions.
Enzyme deficiencies can often translate into life-threatening diseases. For example, a genetic abnormality resulting in the deficiency of the enzyme G6PD...
94.7K
Enzyme Kinetics01:19

Enzyme Kinetics

Enzymes speed up reactions by lowering the activation energy of the reactants. The speed at which the enzyme turns reactants into products is called the rate of reaction. Several factors impact the rate of reaction, including the number of available reactants. Enzyme kinetics is the study of how an enzyme changes the rate of a reaction.
Scientists typically study enzyme kinetics with a fixed amount of enzyme in the controlled environment of a test tube. When more reactant, or substrate, is...
104.1K
Elevation of Intermediate Points on Vertical Curves01:20

Elevation of Intermediate Points on Vertical Curves

Vertical curves are essential in roadway design because they provide smooth transitions between varying roadway grades. Designing vertical curves involves calculating intermediate elevations and identifying the curve's highest or lowest point, which is essential for optimal roadway performance.Intermediate elevations on a vertical curve are determined using the tangent offset method. This method considers the initial elevation at the start of the curve, the grades, and the curve's geometry. The...
295
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.6K