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Updated: Feb 2, 2026

Construction and Characterization of a Novel Vocal Fold Bioreactor
Published on: August 1, 2014
Injection Laryngoplasty for Children with Unilateral Vocal Fold Paralysis: Procedural Limitations and Swallow
Kara D Meister1, April Johnson2, Douglas R Sidell1,3
11 Department of Otolaryngology-Head and Neck Surgery, Stanford University, Palo Alto, California, USA.
Insights
Injection laryngoplasty can help children with vocal fold immobility and dysphagia to advance their diet. This procedure shows a good safety profile in pediatric patients, with timing of surgery being a key factor for success.
Area of Science:
- Pediatric Otolaryngology
- Pediatric Gastroenterology
- Pediatric Surgery
Background:
- Vocal fold immobility in children can lead to significant morbidity, particularly dysphagia.
- Dysphagia in pediatric patients necessitates evaluation and management to improve nutritional intake and reduce complications.
Purpose of the Study:
- To evaluate the efficacy and safety of injection laryngoplasty for treating vocal fold immobility and dysphagia in pediatric patients.
- To identify factors influencing the success of diet advancement following injection laryngoplasty in children.
Main Methods:
- A retrospective case series with chart review was conducted at a tertiary academic children's hospital.
- Included patients were under 12 years of age with unilateral vocal fold immobility, dysphagia, and objective swallow study data.
- Primary outcomes were perioperative adverse events and successful diet advancement, defined by oral feeding initiation or thickener reduction.
Main Results:
- The study included 41 pediatric patients, with 46.3% younger than 18 months.
- Successful diet advancement occurred in 63.63% of patients post-injection laryngoplasty.
- Perioperative adverse events were infrequent, including increased oxygen needs and prolonged operating room time.
Conclusions:
- Injection laryngoplasty is a viable option for improving oral feeding in pediatric patients with vocal fold immobility, even in neonates.
- The procedure is relatively safe, but careful consideration of pediatric-specific limitations is necessary.
- Early surgical intervention (within 6 months of immobility onset) and premorbidity diet appear to predict successful diet advancement.
Objective:
Vocal fold immobility with resultant dysphagia is a known cause of morbidity in the pediatric population. Herein we evaluate the efficacy and adverse events of injection laryngoplasty in children.
Study Design:
Case series with chart review.
Setting:
Tertiary academic children's hospital.
Subjects And Methods:
Patients <12 years of age with unilateral vocal fold immobility, dysphagia, and objective swallow study data were included. Primary outcome measures included perioperative adverse events and the ability to advance the diet, as defined by initiation of oral feeds or reduction in thickener following postoperative swallow study.
Results:
The mean age of the cohort (N = 41) was 43.83 months (range, 0.5-144 months), and 46.3% of patients were <18 months old. Perioperative adverse events included increased oxygen requirement (n = 3), prolonged operating room time secondary to tenuous cardiopulmonary status (n = 2), and postoperative readmission within 30 days (n = 1). A total of 63.63% (n = 21 of 33) of patients safely advanced their diet following objective improvement on swallow study. Patients undergoing injection laryngoplasty ≤6 months of the onset of vocal fold immobility were more likely to advance their diet following surgery.
Conclusion:
Injection laryngoplasty has the potential to advance or initiate an oral diet for children with vocal fold immobility, including those in the first months of life. It is relatively free of adverse events, but certain limitations in the pediatric population must be considered. Preoperative characteristics, including timing of injection and premorbidity diet, may guide clinicians in predicting those patients most likely to advance their diet following injection laryngoplasty.
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