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Related Experiment Video

Updated: Feb 2, 2026

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans

Published on: November 26, 2017

Thermoregulation and age.

Miklós Székely¹, János Garai¹

¹Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.

Handbook of Clinical Neurology

|November 21, 2018

Summary

Thermoregulation is less effective in neonates, children, and the elderly, increasing risks of hypothermia and hyperthermia. Menopause also significantly alters thermoregulatory responses in women.

Keywords:

febrile convulsions hypothermic confusion menopausal hot flushes resting body temperature thermoregulatory effectors thermoregulatory responsiveness thermosensitivity changes

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Area of Science:

Physiology
Gerontology
Pediatrics

Background:

Thermoregulatory functions exhibit significant age-related variations.
Neonates and children possess functional but easily exhausted heat production and loss mechanisms.
Thermosensitivity declines with age, leading to delayed or insufficient responses to thermal challenges.

Purpose of the Study:

To review age-related changes in thermoregulatory functions.
To discuss the implications of these changes for thermoregulation in neonates, children, the elderly, and menopausal women.

Main Methods:

Literature review of thermoregulatory physiology across different age groups.
Analysis of effector mechanisms and thermosensitivity thresholds.
Examination of thermoregulatory responses to thermal challenges and infections.

Main Results:

Neonates and children are prone to hypothermia and hyperthermia due to easily exhaustible mechanisms.
The elderly experience decreased thermosensitivity, delayed responses, and increased susceptibility to temperature dysregulation.
Infections may present with blunted fever or hypothermia in the elderly.
Brain damage can cause specific thermoregulatory disturbances.
Menopause is associated with hot flushes due to estrogen withdrawal, impacting thermoregulation.

Conclusions:

Age significantly impacts the body's ability to maintain thermal homeostasis.
Vulnerable populations, including neonates, children, the elderly, and menopausal women, require specific considerations for thermoregulation.
Further research is needed to fully understand menopausal thermoregulatory anomalies.