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Pyroptosis of HUVECs can be induced by heat stroke

Yanfang Pei1, Yan Geng2, Lei Su3

  • 1The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Emergency, Hunan Provincial People's Hospital, No. 61, Jefang West Road, Changsha, Hunan, China.

Biochemical and Biophysical Research Communications
|November 21, 2018
PubMed

Heat stroke is a serious pathological condition with high mortality. Vascular endothelial cell injury is a key feature in the pathogenesis of heat stroke, but the specific pathophysiological process whereby this occurs is still unclear. Currently, relevant studies are primarily based upon examination of apoptosis. Recently, pyroptosis, a new form of inflammation-related programmed cell death, was also demonstrated to be involved in heat stroke pathophysiology. Herein, we present evidence that vascular endothelial cell pyroptosis can be induced by heat stress in a time- and temperature-dependent manner. Furthermore, this process can be significantly inhibited by GSDMD siRNA. These findings suggest a new therapeutic target for heat stroke.

Keywords:
GSDMDHeat stressHeat strokePyroptosisVascular endothelial cells

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