Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

641
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
641
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

1.0K
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
1.0K
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

1.0K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.0K
Restless Leg Syndrome and Night Terrors01:27

Restless Leg Syndrome and Night Terrors

564
Restless Leg Syndrome (RLS), also known as Willis-Ekbom disease, is a neurological disorder characterized by an uncontrollable urge to move the legs due to uncomfortable sensations. These sensations typically occur during periods of rest or inactivity, particularly when lying down or sitting, and can severely disrupt sleep.
The exact cause of RLS is not fully understood, but it is believed to involve dopamine, a neurotransmitter that helps regulate muscle movement. Imbalances in dopamine levels...
564
Acute Coronary Syndrome V: Nursing Management01:26

Acute Coronary Syndrome V: Nursing Management

326
Nursing Assessment:Nursing management of acute coronary syndrome (ACS) involves taking the patient's history, focusing on primary complaints such as chest pain, dyspnea, and excessive sweating (diaphoresis), as well as other symptoms like back or jaw pain, nausea, vomiting, palpitations, dizziness, and fatigue. The nurse also reviews the patient's history of cardiac events, risk factors such as hypertension, diabetes, smoking, family history, and current medications.In the objective assessment,...
326
Nephrotic Syndrome II : Assessment and Medical Management01:26

Nephrotic Syndrome II : Assessment and Medical Management

241
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
241

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Natural History of C3 Glomerulopathy and Immune Complex-Associated Membranoproliferative Glomerulonephritis in Children.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Blood Pressure Control in Adolescents With CKD and Risk of Kidney Failure in Young Adulthood.

Kidney medicine·2026
Same author

Pegcetacoplan Versus Iptacopan for the Treatment of Patients with C3 Glomerulopathy: Indirect Treatment Comparisons.

Advances in therapy·2026
Same author

Pegcetacoplan for Adolescents with C3 Glomerulopathy or Primary Immune Complex Membranoproliferative GN: Phase 3 VALIANT Subgroup Analysis.

Clinical journal of the American Society of Nephrology : CJASN·2026
Same author

Contemporary Treatment Responses of Recurrent Focal Segmental Glomerulosclerosis or Steroid Resistant Nephrotic Syndrome in Children after Kidney Transplantation: Phase 2 of a Multicenter Electronic Health Record Data Analysis.

Research square·2026
Same author

Comparative Effectiveness of Antihypertensive Medications in Children With Chronic Kidney Disease.

JAMA pediatrics·2026
Same journal

Barriers, Breakthroughs, and the Future of Pediatric Dermatologic Care.

Pediatric clinics of North America·2026
Same journal

Advancing Pediatric Dermatology: Innovations in Care and Access.

Pediatric clinics of North America·2026
Same journal

No Child Left Behind: Advancing Access in Pediatric Dermatology, a 4-Year, Single-Center Experience.

Pediatric clinics of North America·2026
Same journal

Telemedicine and Access to Pediatric Dermatology Care.

Pediatric clinics of North America·2026
Same journal

Inequitable Reimbursement for Pediatric Providers: A Review of Structural Factors that Disincentivize the Care of Children.

Pediatric clinics of North America·2026
Same journal

Medical Photography's Power to Change Medical Care.

Pediatric clinics of North America·2026
See all related articles

Related Experiment Video

Updated: Feb 2, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.1K

Hemolytic Uremic Syndrome.

Ellen M Cody1, Bradley P Dixon2

  • 1Department of Pediatrics, University of Colorado School of Medicine, 13123 East 16th Avenue, Box 158, Aurora, CO 80045, USA.

Pediatric Clinics of North America
|November 21, 2018
PubMed
Summary
This summary is machine-generated.

Hemolytic uremic syndrome (HUS) involves low platelets, anemia, and kidney injury. Different causes, including E. coli and genetic factors, lead to a common pathway of blood clot formation.

Keywords:
Atypical HUSCobalamin CEscherichia coliHemolytic uremic syndromePneumococcal HUSShiga toxin

More Related Videos

Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays
12:12

Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays

Published on: March 29, 2022

3.3K
Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
08:31

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

14.5K

Related Experiment Videos

Last Updated: Feb 2, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

22.1K
Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays
12:12

Identification of Hemolytic and Phospholipase Activity in Crude Extracts from Sea Anemones by Straightforward Bioassays

Published on: March 29, 2022

3.3K
Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome
08:31

Conscious and Non-conscious Representations of Emotional Faces in Asperger's Syndrome

Published on: July 31, 2016

14.5K

Area of Science:

  • Nephrology
  • Hematology
  • Pediatrics

Background:

  • Hemolytic uremic syndrome (HUS) is characterized by thrombocytopenia, anemia, and acute kidney injury.
  • It is classically linked to Shiga toxin-producing Escherichia coli enterocolitis.
  • Other causes include Streptococcus pneumoniae infections, complement pathway dysregulation, coagulation cascade issues, and cobalamin C metabolism disorders.

Purpose of the Study:

  • To differentiate the various mechanisms underlying Hemolytic Uremic Syndrome.
  • To inform optimal therapeutic strategies based on distinct disease pathways.

Main Methods:

  • Review of clinical presentations and etiological factors of HUS.
  • Analysis of the shared prothrombotic and proinflammatory endothelial cell surface pathway.
  • Distinguishing features of HUS subtypes.

Main Results:

  • HUS shares a common final pathway involving endothelial damage, fibrin, and platelet deposition.
  • Diverse triggers converge on this prothrombotic state.
  • Understanding mechanistic differences is crucial for targeted treatment.

Conclusions:

  • Differentiating HUS causes is essential for effective management.
  • Therapeutic interventions should be tailored to the specific underlying mechanism of HUS.
  • Further research into distinguishing HUS entities aids in optimizing patient outcomes.