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Long-Term Outcomes of Kidney Transplantation in Children

Pamela D Winterberg1, Rouba Garro1

  • 1Division of Pediatric Nephrology, Emory University School of Medicine, Children's Pediatric Institute, 2015 Uppergate Drive NE, 5th Floor, Atlanta, GA 30322, USA.

Pediatric Clinics of North America
|November 21, 2018
PubMed

Insights

Kidney transplantation offers superior outcomes for children with end-stage renal disease (ESRD), improving survival and quality of life. Long-term care focuses on managing immunosuppression side effects and supporting development.

Area of Science:

  • Pediatric Nephrology
  • Transplantation Medicine
  • Immunosuppression Management

Background:

  • Kidney transplantation is the primary treatment for pediatric end-stage renal disease (ESRD).
  • It significantly improves survival, growth, quality of life, and neurodevelopment compared to dialysis.
  • Pediatric kidney transplant recipients achieve over 90% 10-year patient survival.

Purpose of the Study:

  • To outline the optimal long-term management strategies for pediatric kidney transplant recipients.
  • To emphasize the importance of minimizing immunosuppression side effects while preventing rejection and infection.
  • To support normal growth, development, and a successful transition to adult care.

Main Methods:

  • This abstract reviews current best practices in pediatric kidney transplantation.
  • It synthesizes data on long-term outcomes and management challenges.
  • Focus is on comprehensive care including immunosuppression, cardiovascular, and metabolic monitoring.

Main Results:

  • Kidney transplantation in children with ESRD demonstrates excellent long-term survival rates exceeding 90% at 10 years.
  • Transplantation leads to better health-related quality of life and neuropsychological development.
  • Effective management minimizes risks associated with immunosuppressive therapies.

Conclusions:

  • Long-term management of pediatric kidney transplant recipients is crucial for sustained health.
  • Key goals include preventing rejection/infection, mitigating immunosuppression side effects, and fostering development.
  • A coordinated transition to adult care ensures continued well-being.

Keywords:
Kidney transplantationOutcomesPediatric

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