Related Experiment Video
Updated: Aug 18, 2026

Human Pluripotent Stem Cell Based Developmental Toxicity Assays for Chemical Safety Screening and Systems Biology Data Generation
Published on: June 17, 2015
The genetic toxicology of some hydrocarbon and oxygenated solvents
T M Brooks1, A L Meyer, D H Hutson
1Shell Research Limited, Sittingbourne Research Centre, Kent, UK.
Abstract:
Two hydrocarbon solvents (heptane and Special Boiling Point Spirit 100/140) and eight oxygenated solvents [methyl ethyl ketone, methyl isobutyl ketone, diacetone alcohol, di-isobutyl ketone, isopropyl ether, hexylene glycol, secondary butyl alcohol and ME 6K (pentoxone)] have been tested for genotoxic activity. The solvents were tested in bacterial mutation assays, a yeast assay for mitotic gene conversion and in cultured mammalian cells (either rat liver or Chinese hamster ovary) for structural chromosome damage. All of the solvents gave a negative response in the bacterial mutation assays and the yeast mitotic gene conversion assay. In the rat liver chromosome assay, diacetone alcohol evoked a weak positive response, the remaining solvents gave a negative response.
More Related Videos
Related Concept Videos
Autoxidation of Ethers to Peroxides and Hydroperoxides
Mutagenicity and Carcinogenicity
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Drug toxicity: Idiosyncratic Reactions
Bioactivation and Tissue Toxicity
Toxicity Testing in Animals

