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Evidence for respiratory viruses interactions in asymptomatic preschool-aged children

K Douros1, D Kotzia1, C Kottaridi2

  • 1Third Department of Pediatrics, University General Hospital "Attikon", School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.

Allergologia Et Immunopathologia
|November 21, 2018
PubMed

Insights

Respiratory viruses like RSV and influenza, and rhinovirus and adenovirus, were found to predict each other

Area of Science:

  • Virology
  • Pediatric Infectious Diseases
  • Epidemiology

Background:

  • Understanding viral interactions is crucial for managing respiratory infections in children.
  • Asymptomatic carriage of respiratory viruses is common in preschool-aged children.
  • The potential for co-infections and viral interference in the upper respiratory tract remains an area of investigation.

Purpose of the Study:

  • To prospectively investigate potential interferences and associations between common respiratory viruses in asymptomatic preschool children.
  • To identify if the presence of one virus predicts the presence of another in the upper respiratory tract.

Main Methods:

  • Prospective collection of nasopharyngeal swabs from 233 preschool children over one school year.
  • Testing of samples for nine respiratory viruses using a RT-PCR DNA/RNA microarray system.
  • Statistical analysis to determine predictive relationships between different viral detections.

Main Results:

  • Respiratory syncytial virus (RSV) predicted the presence of influenza virus (INFL) (OR: 9.12) and vice versa (OR: 4.01).
  • Rhinovirus (RV) predicted the presence of adenovirus (ADV) (OR: 3.66) and vice versa (OR: 4.05).
  • No other significant viral associations were identified among the nine tested viruses.

Conclusions:

  • Respiratory viruses in asymptomatic carriers may interact, potentially facilitating the establishment of other viruses in the upper respiratory tract.
  • The specific pathophysiological mechanisms underlying these observed viral interactions require further elucidation.
  • Findings suggest a complex interplay of viruses even in the absence of overt symptoms.
Abstract

Keywords:
ChildrenInteractionsRespiratory viruses

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