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Autoimmune pancreatitis in children: A single centre experience in diagnosis, management and long term follow up

Huey Miin Lee1, Maesha Deheragoda2, Phil Harrison2

  • 1Paediatric Liver, GI & Nutrition Centre and MowatLabs, King's College Hospital NHS Foundation Trust, London, UK.

Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [Et Al.]
|November 21, 2018
PubMed

Insights

This study of pediatric autoimmune pancreatitis (AIP) found a good long-term prognosis in a small cohort. Further research is needed to fully understand this rare condition in children.

Area of Science:

  • Gastroenterology
  • Pediatric Medicine
  • Immunology

Background:

  • Autoimmune pancreatitis (AIP) is a rare chronic inflammatory condition affecting the pancreas.
  • Limited data exists regarding pediatric AIP, necessitating further characterization.

Purpose of the Study:

  • To detail the presentation, diagnosis, management, and long-term outcomes of pediatric patients with AIP.
  • To contribute to a better understanding of AIP in the pediatric population.

Main Methods:

  • Retrospective review of data from six pediatric patients diagnosed with AIP over a 10-year period.
  • Collected data included demographics, clinical information, laboratory and serological markers, radiological and histological findings, and follow-up data.

Main Results:

  • One patient had Type 1 AIP, while five had Type 2 AIP (definitive, probable, or suspected).
  • Median follow-up was 3.9 years. Four patients underwent pancreatic biopsies, with two showing granulocytic epithelial lesions (GELs).
  • Four patients received steroid treatment; two developed ulcerative colitis. Two patients experienced exocrine insufficiency.

Conclusions:

  • The long-term prognosis for pediatric AIP in this cohort appears favorable.
  • Additional follow-up data is crucial for further defining and characterizing pediatric AIP.
Abstract

Keywords:
Autoimmune pancreatitisChildrenDiagnosisGranulocyte epithelial lesionImmunoglobulin G subclass 4

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