Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The crucible of resilience: hormesis as the unifying principle of evolution, genetics, and epigenetics.

Archives of toxicology·2026
Same author

Hormesis in biomedical and toxicological models: A generalizable phenomenon induced by per- and polyfluoroalkyl agents.

Chemico-biological interactions·2026
Same author

Canine environmental health: An EPA blind spot? Canine physiology, environmental exposure, and the regulatory gap in U.S. policy.

Regulatory toxicology and pharmacology : RTP·2026
Same author

Hormetic effects of per- and polyfluoroalkyl substances on ecologically relevant animal models: Generality, quantitative features, and risk assessment implications.

Environmental pollution (Barking, Essex : 1987)·2026
Same author

How the US NAS BEAR I Genetics Panel scientific misconduct could have been avoided, but was not.

Journal of occupational and environmental hygiene·2026
Same author

BEAR I Genetics Panel: An unexpected and troubling historical twist: The untold story of Hermann Muller's significant scientific confusion.

Journal of occupational and environmental hygiene·2026

Related Experiment Video

Updated: Dec 22, 2025

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.5K

Building Biological Shields via Hormesis.

Edward J Calabrese1, Evgenios Agathokleous2

  • 1Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA 01003, USA.

Trends in Pharmacological Sciences
|November 21, 2018
PubMed
Summary
This summary is machine-generated.

Hormesis, a biological response, can create protective shields against age-related diseases and injuries like traumatic brain injury. Pre- and postconditioning strategies harness hormesis to improve health practices.

Keywords:
adaptive responsedose responsehormesispostconditioningpreconditioningpublic health

More Related Videos

Construction of a Compact Low-Cost Radiation Shield for Air-Temperature Sensors in Ecological Field Studies
05:56

Construction of a Compact Low-Cost Radiation Shield for Air-Temperature Sensors in Ecological Field Studies

Published on: November 6, 2018

8.6K
Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

47.1K

Related Experiment Videos

Last Updated: Dec 22, 2025

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks
04:53

Author Spotlight: Advances in Evaluating Human Lung Epithelial Cells' Response to Metal-Organic Frameworks

Published on: May 26, 2023

1.5K
Construction of a Compact Low-Cost Radiation Shield for Air-Temperature Sensors in Ecological Field Studies
05:56

Construction of a Compact Low-Cost Radiation Shield for Air-Temperature Sensors in Ecological Field Studies

Published on: November 6, 2018

8.6K
Viability Assays for Cells in Culture
12:03

Viability Assays for Cells in Culture

Published on: January 20, 2014

47.1K

Area of Science:

  • Biology
  • Medicine
  • Public Health

Background:

  • Hormesis is a dose-response phenomenon where a beneficial effect occurs at low doses, while higher doses cause toxicity.
  • Age-related diseases and acute trauma pose significant public health challenges.
  • Preconditioning and postconditioning are strategies used to enhance cellular resilience.

Purpose of the Study:

  • To explore the potential of hormesis in developing protective strategies against age-related diseases and acute trauma.
  • To investigate how preconditioning and postconditioning, leveraging hormetic principles, can enhance medical and public health practices.

Main Methods:

  • Review of existing literature on hormesis and its applications in biological pre- and postconditioning.
  • Analysis of studies demonstrating hormetic effects in various biological models.
  • Evaluation of the translational potential of hormesis-based strategies for medical and public health.

Main Results:

  • Hormesis can induce adaptive responses that confer resistance to various stressors.
  • Preconditioning and postconditioning strategies based on hormesis show promise in mitigating damage from age-related diseases and acute trauma.
  • These strategies have the potential to improve patient outcomes and public health interventions.

Conclusions:

  • Hormesis presents a promising framework for developing novel therapeutic and preventative strategies.
  • Hormetic pre- and postconditioning can enhance biological resilience, offering protection against a wide range of health threats.
  • The implementation of hormesis-based approaches could significantly advance medical and public health practices.