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Updated: Feb 2, 2026
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A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
Published on: May 16, 2015
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Urine metabolomic profile in neonates with hypoxic-ischemic encephalopa-thy
K Sarafidis1, N Efstathiou1, O Begou2
11 Department of Neonatology, School of Medicine Aristotle University of Thessaloniki, Thessaloniki, Greece.
Hippokratia
|November 21, 2018
Summary
This study identified distinct urine metabolic profiles in newborns with hypoxemic-ischemic encephalopathy (HIE). These findings reveal biochemical differences and may aid in developing biomarkers for HIE.
Area of Science:
- Neonatal Medicine
- Metabolomics
- Biochemistry
Background:
- Hypoxemic-ischemic encephalopathy (HIE) impacts neonates, and understanding its biochemical derangements is crucial.
- Metabolomics offers a powerful approach to uncover disease-associated metabolic changes.
Purpose of the Study:
- To investigate and characterize urinary metabolic alterations in neonates diagnosed with HIE.
- To compare the metabolic profiles of HIE neonates with those of healthy controls.
Main Methods:
- A prospective, single-center study involving neonates born at ≥ 36 weeks gestation.
- Urine samples were collected from HIE and control groups on days 1, 3, and 9 of life.
- Targeted liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed for metabolomic analysis.
Main Results:
- Twenty-one neonates were studied (13 HIE, 8 controls).
- Statistical analysis revealed significant metabolic differences between HIE and control groups.
- Key discriminant metabolites included pyruvic acid, amino acids, acylcarnitines, inositol, kynurenine, hippuric acid, and vitamins.
Conclusions:
- A specific metabolic signature was identified in neonates with HIE.
- These findings contribute to the understanding of HIE biochemistry.
- The identified metabolic profile holds potential for future biomarker development in HIE.
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