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Updated: Feb 2, 2026
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A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
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Component resolved analysis of ash pollen allergy in Bavaria
Katharina Eder1, Donata Gellrich1, Catalina Meßmer1
1Department of Oto-Rhino-Laryngology, Head & Neck Surgery, Ludwig-Maximilians-University Munich, Marchioninistr. 15, 81377 Munich, Germany.
Summary
Ash pollen allergy is often overlooked, affecting 10% of Germans. Standard skin prick tests and native ash extract serology are most reliable for diagnosing ash pollen sensitization and allergy, with nasal provocation being key for differentiation.
Area of Science:
- Allergy and Immunology
- Environmental Allergens
- Diagnostic Methods
Background:
- Ash pollen sensitization is underestimated, with a 10% prevalence in Germany.
- Overlapping pollination with birch pollen often leads to misdiagnosis of ash pollen allergy.
- Component-resolved diagnostics for ash allergens are not routinely available.
Purpose of the Study:
- To evaluate the diagnostic utility of component-resolved diagnostics for ash pollen allergy.
- To compare the effectiveness of different diagnostic methods for ash pollen sensitization.
- To assess the role of olive pollen components in diagnosing ash pollen allergy.
Main Methods:
- Retrospective analysis of 113 patients with ash pollen sensitization.
- Comparison of skin prick tests, nasal provocation tests, and specific IgE antibody profiles.
- Testing against native ash extract, rOle e 1, nOle e 7, and rOle e 9.
Main Results:
- 58% of sensitized patients had a confirmed ash pollen allergy via nasal provocation.
- Skin prick tests and native ash extract serology detected most sensitized patients.
- Component-resolved diagnostics (rOle e 1, nOle e 7, rOle e 9) showed lower sensitivity and no additional benefit.
Conclusions:
- Skin prick testing and native ash extract serology are reliable for diagnosing ash pollen sensitization in Germany.
- Nasal provocation testing is crucial for differentiating between sensitization and clinical allergy.
- Standard methods remain essential for accurate ash pollen allergy diagnosis and management.
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