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Updated: Feb 2, 2026

In Silico Clinical Trials for Cardiovascular Disease
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LARIAT Trial Updates.

Dan Musat1, Suneet Mittal1

  • 1Valley Health System of NY and NJ, Paramus, NJ.

Journal of Atrial Fibrillation
|November 21, 2018
PubMed
Summary
This summary is machine-generated.

The LARIAT device effectively closes the left atrial appendage (LAA), preventing strokes in patients unable to use anticoagulation. This epicardial ligation shows promise for reducing stroke risk and potentially improving atrial fibrillation ablation success.

Keywords:
Appendage ligationLAA ligationLariat

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Area of Science:

  • Cardiology
  • Medical Devices
  • Stroke Prevention

Background:

  • The left atrial appendage (LAA) is a primary source of thrombus formation, leading to approximately 90% of strokes.
  • Anticoagulation therapy, while effective for stroke prevention, is not suitable for all patients.
  • Percutaneous left atrial appendage (LAA) exclusion techniques offer alternatives for stroke risk reduction.

Purpose of the Study:

  • To review existing trial data on the LARIAT device for LAA exclusion.
  • To evaluate the efficacy and safety of the LARIAT system in stroke risk reduction.
  • To explore the potential of LAA ligation in managing atrial fibrillation.

Main Methods:

  • Review of clinical trial data for the LARIAT device.
  • Analysis of patient outcomes regarding LAA complete closure and safety.
  • Comparison of LARIAT device performance with other LAA closure methods.

Main Results:

  • The LARIAT device achieved high rates of LAA complete closure (92-100%) in over 4500 patients.
  • Improved safety profile observed with evolved pericardial access techniques.
  • LAA closure performance comparable to the Watchman device, with minor leaks not correlating to thromboembolic events.

Conclusions:

  • LAA closure with the LARIAT epicardial suture is a viable alternative for stroke risk reduction in patients contraindicated for anticoagulation.
  • The LARIAT system may enhance the success of atrial fibrillation ablation, particularly for persistent forms, pending further trial results.