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Neuropsychological comparison of incident MCI and prevalent MCI

Allison Hansen1, Richard J Caselli2, Gretchen Schlosser-Covell2

  • 1Translational Neuroscience and Aging Program, Mayo Clinic, Scottsdale, AZ, USA.

Alzheimer'S & Dementia (Amsterdam, Netherlands)
|November 21, 2018
PubMed
Abstract

Insights

Patients diagnosed with mild cognitive impairment (MCI) in clinical settings (prevalent MCI) show worse cognitive function than those diagnosed in research (incident MCI). This highlights the need to differentiate between prevalent and incident MCI in studies.

Area of Science:

  • Neurology
  • Cognitive Science
  • Gerontology

Background:

  • Limited research exists on cognitive differences between mild cognitive impairment (MCI) diagnosed in clinical (prevalent) versus research (incident) settings.
  • Alzheimer's disease progression suggests potential distinctions between these MCI classifications.

Purpose of the Study:

  • To investigate and compare the cognitive performance of prevalent MCI patients versus incident MCI patients.
  • To determine if MCI severity differs based on diagnostic setting.

Main Methods:

  • A comparison was made between 52 prevalent amnestic MCI patients and 53 incident amnestic MCI participants.
  • Neuropsychological data across four cognitive domains and one global measure were analyzed.

Main Results:

  • Prevalent MCI cases demonstrated significantly poorer performance compared to incident MCI cases.
  • This difference was observed in both global cognitive function and specific domain measures.

Conclusions:

  • Patients seeking clinical evaluation for memory loss present with more severe single-domain amnestic MCI than research-identified incident MCI cases.
  • Future studies on MCI should differentiate between incident and prevalent cases, in addition to single- and multiple-domain classifications.
Keywords:
Alzheimer'sCognitive declineCognitive functioningDementiaIncidenceMild cognitive impairmentPrevalence

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