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Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury

Hironori Hara1, Norifumi Takeda1, Masaki Kondo2

  • 1Department of Cardiovascular Medicine, The University of Tokyo Hospital, Tokyo, Japan.

JACC. Basic to Translational Science
|November 21, 2018
PubMed

Keywords:
BIO, (2ʹZ,3ʹE)-6-bromoindirubin-3ʹ-oximeEdU, 5-ethynyl-2ʹ-deoxyuridineFGF1, acidic fibroblast growth factorHippo pathwayMI, myocardial infarctionNRF2, nuclear factor erythroid 2-related factor 2NRG1, neuregulin-1TAZ, transcriptional coactivator with PDZ-binding motifTEAD, transcriptional enhancer factor domainWnt/β-catenin signalingYAP, YES-associated proteinantioxidationmyocardial infarctionregeneration

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