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Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder

Nadia Dehbokri1,2, Gholamreza Noorazar3, Aida Ghaffari4

  • 1Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.

World Journal of Pediatrics : WJP
|November 21, 2018
PubMed

Insights

Oral vitamin D supplementation improved attention-deficit hyperactivity disorder (ADHD) symptoms in children, particularly inattention. This study highlights vitamin D

Area of Science:

  • Pediatric Neurology
  • Nutritional Psychiatry
  • Clinical Trials

Background:

  • Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children.
  • Vitamin D deficiency is prevalent and has been investigated for its potential role in various health conditions, including neurodevelopmental disorders.
  • Previous research suggests a possible link between vitamin D levels and ADHD symptoms, warranting further investigation.

Purpose of the Study:

  • To assess the efficacy of oral vitamin D administration in improving ADHD symptoms in children.
  • To investigate the effect of vitamin D on specific ADHD symptom subscales, including inattention and hyperactivity/impulsivity.
  • To determine if baseline vitamin D levels influence treatment response.

Main Methods:

  • A double-blind, randomized clinical trial involving 96 children aged 2-18 years.
  • Participants received either 50,000 IU of vitamin D weekly or a placebo for six weeks.
  • ADHD symptoms were evaluated using the Conners Parent Rating Scale (CPRS) at baseline and post-intervention. Serum vitamin D levels were also assessed.

Main Results:

  • The vitamin D group showed a significant decrease in the Conners Inattention (IA) score.
  • Children with insufficient baseline vitamin D levels experienced remarkable improvement in overall ADHD symptoms and all subscale scores compared to the placebo group.
  • No significant differences in baseline CPRS scores were observed between the groups.

Conclusions:

  • Oral vitamin D supplementation can effectively improve ADHD symptoms in children, with a notable impact on inattention.
  • The benefits of vitamin D were more pronounced in children with insufficient baseline vitamin D levels.
  • Vitamin D supplementation may be a valuable adjunctive therapy for children diagnosed with ADHD, considering its widespread health benefits.
Abstract

Keywords:
Attention-deficit hyperactivity disorderChildrenConners parent rating scaleVitamin D

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