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Atrial fibrillation in hypertrophic cardiomyopathy: prevalence, clinical impact, and management

Lohit Garg1, Manasvi Gupta2, Syed Rafay Ali Sabzwari3

  • 1Division of Cardiology, Lehigh Valley Health Network, 1200 S. Cedar Crest Blvd, Allentown, PA, 18103, USA. garg.medicine@gmail.com.

Heart Failure Reviews
|November 21, 2018
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) patients frequently develop atrial fibrillation (AF), a serious arrhythmia. Early rhythm control may improve outcomes for HCM patients with AF.

Area of Science:

  • Cardiology
  • Genetics
  • Electrophysiology

Background:

  • Hypertrophic cardiomyopathy (HCM) is a primary genetic heart muscle disease.
  • Atrial fibrillation (AF) is a common complication in HCM, linked to left atrial changes.
  • AF in HCM increases risks of heart failure and blood clots.

Purpose of the Study:

  • To review clinical, ECG, and ECHO predictors of AF in HCM.
  • To outline current AF management strategies in HCM.
  • To discuss the impact of rhythm control on HCM patient outcomes.

Main Methods:

  • Literature review of clinical studies on HCM and AF.
  • Analysis of identified predictors for AF development.
  • Synthesis of evidence regarding AF management and outcomes in HCM.

Main Results:

  • Left atrial size, age, and heart failure class are key AF predictors in HCM.
  • AF management involves rate/rhythm control and anticoagulation.
  • Early rhythm control appears beneficial for HCM patients with AF.

Conclusions:

  • AF is a significant concern in HCM, impacting prognosis.
  • Tailored management focusing on rhythm control and anticoagulation is crucial.
  • Further research supports early rhythm control for improved HCM outcomes.

Keywords:
Antiarrhythmic agentsAtrial fibrillationHypertrophic cardiomyopathyTreatment

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