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[Update of the ESC guidelines 2018 on cardiovascular diseases during pregnancy : Most important facts]
U Seeland1,2, J Bauersachs3, J Roos-Hesselink4
1Institut für Geschlechterforschung in der Medizin (GiM) und Center for Cardiovascular Research (CCR), Charité - Universitätsmedizin Berlin, Hessische Str. 3-4, 10115, Berlin, Deutschland. ute.seeland@charite.de.
Insights
The 2018 ESC guidelines offer updated management for pregnant women with heart disease, introducing new risk classifications and drug safety information. These guidelines aim to reduce maternal mortality from cardiovascular diseases during pregnancy.
Area of Science:
- Cardiology
- Obstetrics
- Maternal Health
Background:
- Heart disease is a leading cause of maternal mortality in Western nations.
- Existing guidelines require updates to reflect current medical knowledge and practices.
Purpose of the Study:
- To present the 2018 European Society of Cardiology (ESC) guidelines for managing cardiovascular diseases in pregnancy.
- To highlight key updates and new recommendations for physicians caring for pregnant patients with heart conditions.
Main Methods:
- Review and synthesis of the latest research and clinical evidence on cardiovascular diseases in pregnancy.
- Development of updated recommendations based on expert consensus and new data.
Main Results:
- Introduction of the modified World Health Organization (mWHO) classification for maternal risk assessment.
- Establishment of the pregnancy heart team concept for multidisciplinary care.
- Updated guidance on assisted reproductive therapy, anticoagulation, and bromocriptine use in peripartum cardiomyopathy.
- Discontinuation of FDA A-D and X categories for drug safety; inclusion of detailed maternal and fetal risk data.
Conclusions:
- The 2018 ESC guidelines provide a comprehensive, updated framework for managing pregnant women with cardiovascular diseases.
- These guidelines incorporate novel risk stratification, therapeutic strategies, and drug safety information to improve maternal and fetal outcomes.
Abstract:
Heart diseases are the most common cause of maternal death during pregnancy in Western countries. The current ESC guidelines 2018 for the management of cardiovascular diseases during pregnancy is a guide for any physician facing the challenge of caring for pregnant women with cardiovascular diseases. Among the new concepts compared to 2011, are recommendations to classify maternal risk due to the modified World Health Organization (mWHO) classification, introduction of the pregnancy heart team, guidance on assisted reproductive therapy, specific recommendations on anticoagulation for low-dose and high-dose requirements of vitamin K antagonists and the potential use of bromocriptine in peripartum cardiomyopathy. The Food and Drug Administration (FDA) categories A-D and X should no longer be used. Therefore, the table of drugs was completed with detailed information from animal and human studies on maternal and fetal risks. The new findings on specific heart diseases are presented in detail in the respective chapters.
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