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Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
Published on: March 1, 2024
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Psoriasis and cardiovascular disease: the elusive link
Antonis A Manolis1, Theodora A Manolis2, Helen Melita3
1a Patras University School of Medicine , Patras , Greece.
International Reviews of Immunology
|November 21, 2018
Summary
Psoriasis and psoriatic arthritis are linked to cardiovascular disease (CVD), increasing risks. While observational data suggest a connection, further research is needed to confirm this association and the cardiovascular benefits of new biologic therapies.
Area of Science:
- Immunodermatology
- Cardiology
- Rheumatology
Background:
- Psoriasis is an autoimmune inflammatory disease.
- Psoriatic arthritis is a common comorbidity.
- Growing evidence links psoriasis and psoriatic arthritis to cardiovascular disease (CVD).
Purpose of the Study:
- To review the association between psoriasis and CVD.
- To discuss the potential pathogenetic links between these systemic diseases.
- To explore the cardiovascular benefits of newer anti-psoriatic biologic therapies.
Main Methods:
- Review of observational studies and meta-analyses.
- Discussion of existing evidence on the psoriasis-CVD link.
- Consideration of data on biologic therapies and cardiovascular outcomes.
Main Results:
- Observational data suggest an increased risk of cardiovascular events and mortality in patients with psoriasis.
- A potential pathogenetic link between psoriasis and CVD is indicated, but requires further confirmation.
- Newer biologic therapies may offer cardiovascular benefits, pending randomized controlled studies.
Conclusions:
- The association between psoriasis and CVD is complex and warrants further investigation.
- Prospective studies are crucial to establish a definitive link and causality.
- Future research should focus on confirming the cardiovascular benefits of anti-psoriatic treatments.
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