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The Potential of Receptor for Advanced Glycation End Products (RAGE) as a Therapeutic Target for Lung Associated

Tejinder Pal Khaket1, Sun Chul Kang1, Tapan Kumar Mukherjee2

  • 1Department of Biotechnology, Daegu University, Gyeongsan, Gyeongbuk, Korea.

Current Drug Targets
|November 21, 2018
PubMed

Insights

The receptor for advanced glycation end products (RAGE) plays a key role in lung health. Blocking RAGE offers potential therapies for various lung diseases driven by inflammation and oxidative stress.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Cell Biology

Background:

  • The receptor for advanced glycation end products (RAGE) is crucial for lung epithelial cell structure.
  • Supraphysiological levels of RAGE and its ligands are implicated in lung diseases.
  • RAGE activation triggers inflammation and oxidative stress.

Purpose of the Study:

  • To review the functions of RAGE in lung-associated diseases.
  • To highlight the therapeutic potential of targeting RAGE.

Main Methods:

  • Literature review of RAGE's role in pulmonary pathophysiology.
  • Analysis of RAGE signaling pathways in disease contexts.

Main Results:

  • RAGE ligands (AGEs, HMGB1, S100 proteins) activate RAGE, promoting inflammation.
  • RAGE dysregulation contributes to asthma, COPD, lung cancer, fibrosis, ALI, pneumonia, BPD, CF, and sepsis.
  • Inhibition of RAGE presents a promising therapeutic strategy.

Conclusions:

  • RAGE is a significant contributor to the pathogenesis of numerous lung diseases.
  • Targeting RAGE offers a potential therapeutic avenue for treating inflammatory and fibrotic lung conditions.
Keywords:
LungRAGEanti-RAGE therapyinflammationlung epithelial cellspulmonary diseases.

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