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Scientometric Analysis of SIRT6 Studies.
Kaining Lu1,2, Shan Yu3, Dan Sun1,2
1Department of Urology, The First Hospital of China Medical University, Shenyang, Liaoning, China (mainland).
Summary
SIRT6, a key epigenetic molecule, regulates chromatin, lifespan, DNA damage, and metabolism. Research highlights its role in tumors and neural diseases, with foundational work by Motoslavsky, Kawahara, and Kim.
Area of Science:
- Epigenetics
- Molecular Biology
- Bioinformatics
Background:
- SIRT6 is a molecule of significant interest in epigenetics.
- Understanding its bibliometric features is crucial for future research directions.
Purpose of the Study:
- To explore research hotspots and bibliometric features of SIRT6.
- To establish a comprehensive scientometric analysis model for SIRT6 research.
Main Methods:
- Bibliometric analysis of 441 SIRT6 articles from Web of Science.
- Utilized Bicomb, Gcluto, EXCEL, Citespace, CitNetExplorer, and Vosviewer for keyword extraction, clustering, co-citation, citation, and journal analysis.
Main Results:
- Identified key research hotspots and foundational knowledge through co-word and co-citation network analysis.
- Strategic coordinates revealed research prospects and interconnections.
- Discipline and journal distribution analyzed, with term density and dual-map construction.
Conclusions:
- SIRT6's core intellectual basis involves chromatin regulation, lifespan, DNA damage, and metabolism.
- Current research focuses on SIRT6 in tumors and neural diseases.
- Further analysis needed on SIRT6's role in complex biological systems.
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