Three-Component Oxyarylation of Alkenes Enables Access to C3-Substituted Dihydrobenzofurans
Guidong Feng1, Shutao Sun1, Guoliang Liu1
1School of Pharmaceutical Sciences , Shandong University , Jinan 250012 , China.
Abstract:
A practical and modular three-component alkene oxyarylation with benzoquinone and H2O to rapidly access C3-substituted dihydrobenzofurans has been developed. The (NH4)2S2O8-mediated redox-relay process has an excellent regioselectivity and functional group tolerance and exhibits a broad scope of simple alkenes, rapidly furnishing a variety of the substructures that would require multiple steps to prepare with traditional methods. Mechanistic studies revealed a dual role of benzoquinone serving as both the arylation agent and the origin of dihydroquinone for the reductive cyclization step.
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