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Published on: August 15, 2016
Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins
Bakhtiyar S Temirgaziyev1, Karolína Kučáková2, Yerassyl A Baizhigit3
1International Research and Production Holding "Phytochemistry", 470000 Karaganda, Kazakhstan; Buketov Karaganda State University, 100028 Karaganda, Kazakhstan.
Abstract:
20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexation of the phytoecdysteroid with β-cyclodextrin was studied by NMR spectroscopy. By studying the changes in chemical shifts of protons of substrates and receptors it was found that ecdysterone interacts with cyclodextrins to form supramolecular inclusion complexes of stoichiometric composition of 1:1 or 1:2. Ecdysterone-β-cyclodextrin complexes exhibit 100 times higher solubility in water than the parent compound.
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