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Updated: Feb 2, 2026

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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
Published on: May 17, 2019
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Prognostic Value of microRNA-133a Expression and Its Clinicopathologic Significance in Non-Small Cell Lung Cancer: A
Oncology Research and Treatment
|November 21, 2018
Summary
High microRNA-133a (miR-133a) expression in non-small cell lung cancer (NSCLC) indicates better survival. This study confirms miR-133a as a potential prognostic and diagnostic biomarker for NSCLC.
Area of Science:
- Oncology
- Molecular Biology
- Biomarker Discovery
Background:
- The role of microRNA-133a (miR-133a) in non-small cell lung cancers (NSCLCs) remains controversial.
- A comprehensive investigation is needed to clarify its clinical significance.
Purpose of the Study:
- To evaluate the prognostic and diagnostic value of miR-133a in NSCLC.
- To analyze the association between miR-133a expression and clinicopathological features of NSCLC.
Main Methods:
- Meta-analysis of 5 studies (364 patients) and analysis of The Cancer Genome Atlas (TCGA) database (984 patients).
- Statistical analysis performed using Stata 12.0 and R 3.5.0.
Main Results:
- High miR-133a expression was significantly associated with favorable survival outcomes in NSCLC patients (HR 0.561, p=0.001).
- miR-133a-3p demonstrated high diagnostic accuracy (AUC=0.902) and correlated with NSCLC clinicopathologic parameters (p<0.05), including sex, age, social status, and lymph node metastasis.
Conclusions:
- miR-133a may function as a tumor suppressor in NSCLC.
- miR-133a is a promising independent prognostic and diagnostic biomarker for NSCLC, with high expression linked to better patient prognosis.
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