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[Skeletal changes following long-term treatment with retinoids]
1Institut für Klinische Radiologie der Westfälischen Wilhelms-Universität, Münster.
Der Radiologe
|July 1, 1988
Summary
Synthetic retinoids like etretinate and isotretinoin are vital in dermatology. Long-term use may lead to skeletal changes, including osteoporosis and diffuse idiopathic skeletal hyperostosis (DISH).
Area of Science:
- Dermatology
- Rheumatology
- Radiology
Background:
- Synthetic retinoids, vitamin-D derivatives like etretinate and isotretinoin, are crucial in dermatology.
- They are prescribed for severe acne and cornification disorders, often requiring long-term treatment.
Purpose of the Study:
- To investigate skeletal side effects associated with long-term synthetic retinoid therapy.
- To analyze literature reports and clinical observations of retinoid-induced skeletal changes.
Main Methods:
- Literature review of retinoid side effects.
- Radiological assessment of 31 patients undergoing long-term retinoid treatment at two university hospitals.
Main Results:
- Long-term retinoid therapy can cause skeletal side effects.
- Radiological skeletal changes were observed in 3 out of 31 patients.
- Observed changes included osteoporosis, premature epiphyseal closure, and diffuse idiopathic skeletal hyperostosis (DISH)-like alterations.
Conclusions:
- Synthetic retinoids, while effective, carry risks of skeletal adverse events.
- Monitoring for skeletal changes is recommended in patients on long-term retinoid treatment.
- Further research into the mechanisms and prevalence of these side effects is warranted.