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Updated: Feb 2, 2026

A Preclinical Model of Exertional Heat Stroke in Mice

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Heatstroke.

Saeed Al Mahri¹, Abderrezak Bouchama¹

¹Intensive Care Unit and Experimental Medicine Department, King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, Ministry of National Guard Health Affairs, Riyadh, Saudi Arabia.

Handbook of Clinical Neurology

|November 22, 2018

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Heatstroke is a fatal emergency if untreated. Prompt cooling is crucial for hyperthermic patients with altered mental status to prevent organ damage and death.

Area of Science:

Environmental Medicine
Emergency Medicine
Cellular Physiology

Background:

Heatstroke is a life-threatening medical emergency.
It is characterized by hyperthermia and altered mental status.
Heat exposure can lead to severe cellular damage and multiple-organ failure.

Purpose of the Study:

To define the critical factors in diagnosing and managing heatstroke.
To emphasize the importance of immediate cooling interventions.
To highlight the cellular mechanisms underlying heatstroke pathology.

Main Methods:

Clinical diagnosis criteria for heatstroke.
Understanding the pathophysiology of heat-induced cellular damage.
Review of treatment protocols focusing on rapid cooling.

Keywords:

heat shock proteins heat wave heatstroke hyperthermia thermoregulation

Related Experiment Videos

Last Updated: Feb 2, 2026

A Preclinical Model of Exertional Heat Stroke in Mice

A Preclinical Model of Exertional Heat Stroke in Mice

Published on: July 1, 2021

Main Results:

Heatstroke diagnosis requires considering hyperthermia and altered mental status, especially during heat waves or exertion.
Heat damages vital macromolecules like proteins and lipids.
The severity of heatstroke correlates with hyperthermia's degree and duration.

Conclusions:

Early diagnosis and rapid cooling are essential to prevent fatal outcomes.
Prompt intervention halts the progression of tissue damage.
Understanding heat's cytotoxic effects is key to effective heatstroke management.